![]() ![]() Received: AugAccepted: FebruPublished: March 16, 2023Ĭopyright: © 2023 Im et al. PLoS Biol 21(3):Īcademic Editor: Tobias Bollenbach, Universitat zu Koln, GERMANY (2023) Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease. Our results indicate fermentation enzymes are de novo targets for antibiotic development and a novel strategy to combat multidrug-resistant pathogens.Ĭitation: Im H, Pearson ML, Martinez E, Cichos KH, Song X, Kruckow KL, et al. Blocking of alcohol dehydrogenase activity with 4-methylpyrazole (fomepizole), an FDA-approved drug used as an antidote for toxic alcohol ingestion, enhanced susceptibility of multidrug-resistant Spn to erythromycin and reduced bacterial burden in the lungs of mice with pneumonia and prevented the development of invasive disease. Redox balance disruption in fermentation pathway-specific fashion substantially enhanced susceptibility to killing in antimicrobial class-specific manner. ![]() Using a panel of isogenic mutants deficient in lactate, acetyl-CoA, and ethanol fermentation, as well as pharmacological inhibition, we observed that NAD(H) redox balance during fermentation was vital for Spn energy generation, capsule production, and in vivo fitness. One such pathogen is Streptococcus pneumoniae ( Spn), a leading cause of community-acquired pneumonia, bacteremia/sepsis, and meningitis. Anaerobic bacteria are responsible for half of all pulmonary infections. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |